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Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
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Interoception and drug addiction.

Martin P Paulus1, Jennifer L Stewart

  • 1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA; Psychiatry Service, VA San Diego Healthcare System, La Jolla, CA, USA.

Neuropharmacology
|July 17, 2013
PubMed
Summary
This summary is machine-generated.

Interoception, the processing of body signals, plays a key role in drug addiction by influencing motivated behavior. Targeting the insular cortex offers potential interventions for addiction treatment.

Keywords:
Cue reactivityEmbodimentInsulaInteroceptionRelapse

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Area of Science:

  • Neuroscience
  • Addiction Research
  • Psychology

Background:

  • Interoception involves processing internal body signals to guide behavior.
  • The insular cortex is a critical brain region for integrating interoceptive information.
  • Interoception is linked to key addiction-related factors like arousal, stress, and reward.

Purpose of the Study:

  • To review the role of interoception and its neural underpinnings in drug addiction.
  • To explore how interoceptive processing influences motivated behaviors in addiction.
  • To discuss potential therapeutic interventions targeting interoceptive mechanisms.

Main Methods:

  • Literature review of neuroimaging studies and theoretical frameworks.
  • Analysis of the insular cortex's function in addiction.
  • Examination of interoception's contribution to addiction-related constructs.

Main Results:

  • The insular cortex shows altered activity in drug-addicted individuals (hypoactive in cognitive control, hyperactive in cue reactivity).
  • Interoception may contribute to addiction by creating an 'embodied' drug experience influencing approach/avoidance behaviors.
  • Altered interoceptive processing can link drug use to internal states, modulating drug-seeking behavior.

Conclusions:

  • Interoception significantly contributes to the development and maintenance of drug addiction.
  • Modulating insular cortex activity and enhancing cognitive control present potential intervention strategies.
  • Understanding interoception offers novel avenues for addiction treatment by targeting the brain's internal state monitoring systems.