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Updated: May 9, 2026

Tuina Intervention in Rabbit Model of Knee Osteoarthritis
Published on: August 25, 2023
Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy
Abstract:
Wnt and Rho GTPase signaling play critical roles in governing numerous aspects of cell physiology, and have been shown to be involved in endochondral ossification and osteoarthritis (OA) development. In this review, current studies of canonical Wnt signaling in OA development, together with the differential roles of Rho GTPases in chondrocyte maturation and OA pathology are critically summarized. Based on the current scientific literature together with our preliminary results, the strategy of targeting Wnt and Rho GTPase for OA prognosis and therapy is suggested, which is instructive for clinical treatment of the disease.
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