A Post-processing framework for localized 2D MR spectroscopy in vivo.

Area of Science:

• Magnetic Resonance Spectroscopy (MRS)
• In Vivo Imaging
• Neuroimaging

Background:

• Localized 2D MRS provides valuable metabolic information in vivo.
• Conventional methods face challenges with spectral quality due to artifacts like eddy currents and motion.

Purpose of the Study:

• To introduce and validate a novel post-processing framework for localized 2D MRS in vivo.
• To improve spectral quality and quantitation by addressing eddy current and motion artifacts.

Main Methods:

• Developed a framework incorporating eddy current and subject motion correction for localized 2D MRS.
• Eddy current correction involved phase correction of metabolite signals using water signals.
• Motion correction focused on phase correction of specific metabolite peaks (e.g., NAA) after frequency drift correction.

Main Results:

• Eddy current correction resulted in symmetric singlet patterns in phantom spectra, resolving asymmetry.
• Motion correction effectively suppressed t1 noise in human brain spectra, which was present without correction.
• The framework was applied to localized 2D constant-time correlation spectroscopy (CT-COSY) data.

Conclusions:

• The proposed post-processing framework significantly improves the quality of in vivo 2D MRS spectra.
• This advancement holds potential for enhanced quantitation and robustness in in vivo 2D spectroscopic studies.