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Updated: May 9, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
White matter hyperintensities, executive function and global cognitive performance in vascular mild cognitive
Felipe Kenji Sudo1, Carlos Eduardo Oliveira Alves, Gilberto Sousa Alves
1Instituto de Psiquiatria, Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ, Brazil. fksudo@gmail.com
Vascular mild cognitive impairment (VaMCI) is linked to fronto-executive dysfunction. Increased white matter hyperintensities correlate with poorer cognition and executive function deficits in VaMCI patients.
Area of Science:
- Neurology
- Neuropsychology
- Gerontology
Background:
- Vascular mild cognitive impairment (VaMCI) is an early stage of vascular cognitive impairment.
- VaMCI is often associated with fronto-executive dysfunction.
Purpose of the Study:
- To investigate the relationship between white matter hyperintensities and cognitive function in VaMCI.
- To compare cognitive performance between VaMCI individuals and normal controls.
Main Methods:
- Neuropsychological assessment and neuroimaging were used to select 26 participants (15 VaMCI, 11 NC).
- Clinical and neuroimaging data were compared between groups and correlated with the Fazekas scale.
Main Results:
- VaMCI patients showed significantly worse performance in Trail-Making Test B, errors, TMT B-A difference, and CAMCOG scores compared to normal controls.
- Correlations were found between Fazekas scale scores and performance on TMT B, TMT B-A difference, and CAMCOG total score.
Conclusions:
- White matter hyperintensities are associated with poorer global cognition in VaMCI.
- Extension of white matter hyperintensities correlates with impairments in cognitive speed, set shifting, and inhibitory control.
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