[Mechanisms of antioedemic effect of bioflavonoids in experiment]

In treatment of various-aetiology chronic oedemas, of great importance is a possibility of exerting an influence on the resorptional, transportation and transmission functions of the lymphatic system, as well as on the microcirculatory blood channel, because they all maintain the balance of fluid exchange in tissues. There exist various causes of chronic oedema, which requires a differentiated approach to administration of bioflavonoids possessing different mechanisms of antioedemic action. With this in mind we carried out experimental histomorphometric studies on 24 rats, aimed at determining variously directed effects of agents belonging to the class of bioflavonoids - phlebodia 600 (diosmin) and troxerutin on regeneration ability of the lymphatic endothelium and permeability of blood capillaries. It was determined that phlebodia 600 exerts a direct influence upon the functional state of the lymphatic system, activating proliferation of the lymphatic endothelium by means of gemmation, which leads to the formation of new capillary lymphatic networks with the resulting increase in both the total absorption area of the lymphatic capillary networks and the volume of lymph reabsorption. Troxerutin acts predominantly on the endothelium of blood capillaries, decreasing permeability in the arterial segment of the capillary, thus lowering the total volume of fluid in the interstitial space and accordingly the load on the lymphatic system.