Related Experiment Videos
Detection in non-erythroid cells of a factor with the binding characteristics of the erythroid cell transcription
N D Perkins1, K H Orchard, M L Collins
1Institute of Cancer Research, Chester Beatty Laboratories, London, U.K.
The Biochemical Journal
|July 15, 1990
Abstract:
The erythroid transcription factor erythroid factor-1 (EF1) plays a critical role in the transcription of erythroid-specific genes. Here we report the presence of a factor with the mobility and sequence-specific DNA-binding characteristics of EF1 at low abundance in a wide variety of non-erythroid cell types. This is the first report of an EF1-like activity in non-erythroid cells and indicates that this factor may play a role in the regulation of genes expressed in such cells.