Metabolism of phosphatidylinositides in rabbit red blood cells

The particularly strong maturational loss of the monoester phosphate group turnover in PIP2 was demonstrated by in vivo as well as in vitro studies with rabbit reticulocytes. Both cycles of the phosphatidylinositide metabolism (PPI) were relatively insensitive against oxidative stress. Surprisingly, at high concentrations diamide did not alter the PIP2-, indeed, the PIP-turnover was drastically decreased.