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A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible
Published on: January 28, 2020
Tissue-engineered mandibular bone reconstruction for continuity defects: a systematic approach to the literature
Nattharee Chanchareonsook1, Rüdiger Junker, Leenaporn Jongpaiboonkit
11 Department of Oral and Maxillofacial Surgery, National Dental Centre Singapore , Singapore, Singapore .
Tissue Engineering. Part B, Reviews
|July 20, 2013
Summary
Tissue engineering shows promise for mandibular reconstruction, offering an alternative to autogenous bone grafts. Current preclinical and clinical data are limited but suggest potential for treating mandibular defects.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Oral and Maxillofacial Surgery
Background:
- Segmental mandibular bone repair presents ongoing surgical challenges.
- Tissue engineering emerges as a potential advancement for mandibular reconstruction.
Purpose of the Study:
- Systematically review preclinical and clinical literature on bone tissue engineering for mandibular defects.
- Analyze the effectiveness of tissue-engineered mandibular reconstruction.
Main Methods:
- Conducted systematic literature searches in PubMed and Web of Science.
- Included English-language publications on animal and human studies.
- Evaluated histology, bone bridging, biomechanical properties, scaffold degradation, and wound healing.
Main Results:
- Identified 29 animal and 11 human studies for review.
- Data from preclinical and clinical studies are currently limited.
- Tissue-engineered methods showed some clinical potential.
Conclusions:
- Published preclinical and clinical data on mandibular tissue engineering are scarce.
- Tissue-engineered approaches present a viable alternative to autogenous bone grafting for mandibular defects.
