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Related Experiment Video

Updated: May 9, 2026

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing

An Experimental Paradigm for Measuring the Effects of Ageing on Sentence Processing

Published on: October 25, 2019

Functional and structural syntax networks in aging.

Daria Antonenko¹, Jens Brauer, Marcus Meinzer

¹Department of Neurology, NeuroCure Cluster of Excellence, and Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Germany.

|July 23, 2013

Summary

This summary is machine-generated.

Older adults show reduced syntactic ability linked to weaker brain network connectivity. Young adults rely on dorsal tracts, while older adults utilize ventral tracts for syntax, impacting performance differently.

Keywords:

Connectivity Functional imaging Language Resting-state White matter integrity

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Area of Science:

Neuroscience
Cognitive Aging
Psycholinguistics

Background:

Language abilities, particularly syntax, decline with age.
This decline may stem from reduced functional and structural brain connectivity.
Understanding these changes is crucial for addressing age-related cognitive decline.

Purpose of the Study:

To investigate syntactic ability in young and older adults.
To assess the relationship between behavioral performance and brain connectivity (functional and structural).
To explore age-related differences in brain network utilization for syntax.

Main Methods:

Utilized resting-state functional magnetic resonance imaging (fMRI) for functional connectivity (FC).
Employed diffusion-weighted imaging (DWI) for structural connectivity (SC) analysis.
Assessed syntactic performance behaviorally and correlated it with FC from the left pars opercularis and SC of specific white matter tracts (SLF, UF, forceps minor).

Main Results:

Young adults outperformed older adults in syntax and showed stronger, beneficial FC within the syntax network.
Older adults exhibited reduced FC within the syntax network, with detrimental inter-hemispheric FC.
Both groups showed positive correlation between performance and inter-hemispheric SC; intra-hemispheric SC correlations differed (SLF for young, UF for older adults).

Conclusions:

Reduced syntactic ability in aging is associated with decreased functional connectivity within syntax networks.
Young adults' syntactic performance correlates with dorsal tract integrity (SLF), while older adults rely more on ventral tracts (UF).
The study provides novel insights into age-related changes in brain organization and connectivity, crucial for developing interventions against cognitive decline.