Related Experiment Video
Updated: May 9, 2026
09:01
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
Eosinophilic presentation of acute lymphoblastic leukemia
Azim Rezamand1, Ziaaedin Ghorashi, Sona Ghorashi
1Department of Pediatrics, Tabriz University (Medical Sciences), Tabriz, Iran.
The American Journal of Case Reports
|July 23, 2013
Summary
Acute lymphoblastic leukemia (ALL) can rarely present with severe eosinophilia in children, mimicking appendicitis. Prompt diagnosis and intensive chemotherapy are crucial for successful treatment and remission in these rare pediatric oncology cases.
Area of Science:
- Pediatric Oncology
- Hematology
- Rare Diseases
Background:
- Leukemias are common childhood cancers, with acute lymphoblastic leukemia (ALL) comprising 77% of cases.
- In rare instances, pediatric ALL patients may exhibit eosinophilia.
- Eosinophilia can complicate the diagnosis of common childhood conditions.
Purpose of the Study:
- To report a rare case of acute lymphoblastic leukemia (ALL) presenting with severe eosinophilia in a pediatric patient.
- To highlight the diagnostic challenges and importance of early intervention in such cases.
Main Methods:
- A 5-year-old boy presented with symptoms initially suggestive of appendicitis.
- Diagnostic workup included complete blood count (revealing leukocytosis with severe eosinophilia), bone marrow aspirations, and flow cytometry.
- Treatment involved standard chemotherapy protocols for ALL.
Main Results:
- The patient was diagnosed with acute lymphoblastic leukemia (ALL) despite initial presentation mimicking appendicitis.
- Following chemotherapy, the patient achieved disease remission and successful treatment after 2 years.
Conclusions:
- Acute lymphoblastic leukemia (ALL) can be diagnosed in rare cases presenting with eosinophilia.
- Patients with ALL and hypereosinophilia require immediate diagnosis and intensive therapy due to a potentially worsened prognosis.
Related Concept Videos
01:27Disorders of Leukocytes
Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
01:16Primary Lymphoid Organs
Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...