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Updated: May 9, 2026
12:04
Examination of Mitotic and Meiotic Fission Yeast Nuclear Dynamics by Fluorescence Live-cell Microscopy
Published on: June 24, 2019
Aging: seeking mitonuclear balance.
Jason Karpac1, Heinrich Jasper
1Buck Institute for Research on Aging, Novato, CA 94945, USA.
Cell
|July 23, 2013
Summary
Metabolic imbalances during aging can be managed by specific signaling networks. These networks, involving mitochondrial stress responses, promote longevity by regulating mitochondrial translation and NAD(+) metabolism.
Area of Science:
- Gerontology and cellular metabolism.
- Mitochondrial biology and aging research.
Background:
- Aging is associated with metabolic dysregulation in many organisms.
- Signaling pathways that counteract metabolic imbalances can potentially extend lifespan.
Purpose of the Study:
- To identify conserved signaling networks involved in aging and longevity.
- To understand the role of mitochondrial stress responses in metabolic homeostasis and lifespan extension.
Main Methods:
- Analysis of conserved signaling networks.
- Investigation of mitochondrial stress responses.
- Examination of mitochondrial translation and NAD(+) metabolism.
Main Results:
- A conserved signaling network centered on mitochondrial stress responses was identified.
- This network promotes longevity in response to alterations in mitochondrial translation.
- Changes in NAD(+) metabolism are linked to this longevity-promoting network.
Conclusions:
- Mitochondrial stress response signaling is a key regulator of aging and lifespan.
- Targeting this network may offer strategies to combat age-related metabolic decline and extend healthspan.
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