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Updated: May 9, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
Published on: November 22, 2019
Does the microenvironment influence the cell types of origin for prostate cancer?
Andrew S Goldstein1, Owen N Witte
1Department of Molecular and Medical Pharmacology, Howard Hughes Medical Institute, University of California at LosAngeles, Los Angeles, California 90095, USA.
Abstract:
Despite several recent studies addressing the cells of origin for prostate cancer, there is still considerable discussion in the field regarding the most relevant target populations for transformation. Tissue regeneration studies have pointed to a basal cell origin for mouse and human prostate cancer. In contrast, genetically engineered mouse models demonstrate that cells within both the basal and luminal layers can initiate murine prostate cancer. Based on differences between these two approaches, we propose that further work should address the requirement for microenvironmental components such as immune or mesenchymal cells on epithelial cell types of origin for prostate cancer.
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