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Related Experiment Video

Updated: May 9, 2026

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs
07:55

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs

Published on: December 13, 2019

Design for a lithographically patterned bioartificial endocrine pancreas.

Jaehyun Park1, Yevgeniy V Kalinin, Sachin Kadam

  • 1Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.

Artificial Organs
|July 24, 2013
PubMed
Summary

This study presents a novel bioartificial endocrine pancreas (BAEP) using precise micro-fabrication to overcome oxygen transport challenges for cell encapsulation therapy in diabetes treatment.

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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Cell encapsulation is a promising strategy for treating diseases like diabetes.
  • Transplanting billions of cells for human diabetes therapy poses significant mass transport challenges, particularly oxygen supply.

Purpose of the Study:

  • To demonstrate a proof-of-concept for a bioartificial endocrine pancreas (BAEP) designed to minimize hypoxia.
  • To develop a scalable and precisely architected device for therapeutic cell transplantation.

Main Methods:

  • Utilized a combination of computational simulations and experimental validation.
  • Engineered a BAEP using lithographically patterned porous polyhedral capsules on a rolled alginate sheet.
  • Precisely controlled structural variables including capsule dimensions, pore characteristics, and spacing.
Keywords:
BioMEMSBioartificial pancreasCell encapsulation therapyDiabetesInsulinNanotechnology

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Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology
08:16

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology

Published on: March 15, 2024

Related Experiment Videos

Last Updated: May 9, 2026

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs
07:55

Pancreatic Tissue-Derived Extracellular Matrix Bioink for Printing 3D Cell-Laden Pancreatic Tissue Constructs

Published on: December 13, 2019

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology
08:16

Generating Human Pancreatic Tissue Slices to Study Endocrine and Exocrine Pancreas Physiology

Published on: March 15, 2024

Main Results:

  • Achieved efficient mass transport with no cell located more than 200 μm from the surrounding medium.
  • Demonstrated unprecedented precision and tunability in structural parameters and encapsulated cell volume compared to gel-based methods.
  • Fabricated a single device with a volume only slightly larger than the total cell volume.

Conclusions:

  • The developed BAEP architecture effectively minimizes hypoxia in large-scale cell encapsulation.
  • Lithography and self-assembly are powerful tools for creating micro/nanostructured 3D devices that mimic natural organ function.
  • This approach offers enhanced control over insulin secretion by precisely managing encapsulated cell volume.