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Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a result, EDTA...

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Related Experiment Video

Updated: May 9, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

[Pitfall in coagulation tests].

Anita Gähler1, Walter A Wuillemin

  • 1Abteilung für Hämatologie und Hämatologisches Zentrallabor, Luzerner Kantonsspital, Luzern. anita.gaehler@luks.ch

Therapeutische Umschau. Revue Therapeutique
|July 24, 2013
PubMed
Summary
This summary is machine-generated.

Coagulation testing requires careful interpretation due to pre-analytical issues and drug interactions. Understanding patient anticoagulants and clinical status is crucial for accurate results.

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Area of Science:

  • Clinical Biochemistry
  • Hematology
  • Pharmacology

Background:

  • Coagulation assays are susceptible to pre-analytical variables and clinical factors.
  • Anticoagulants significantly impact coagulation test results through various mechanisms.

Observation:

  • Vitamin K antagonists cause dose-dependent prolongation of thromboplastin time.
  • Newer oral anticoagulants exhibit variable effects on thromboplastin time and other coagulation tests.
  • Measuring anti-Xa activity is affected by all anti-Xa agents, including heparins and inhibitors.

Findings:

  • Accurate interpretation necessitates laboratory awareness of patient anticoagulant therapy.
  • Specific calibration curves are essential for reliable anti-Xa activity measurements.
  • Clinical context, including bleeding disorders and thromboembolic events, is vital for correct interpretation.

Implications:

  • Laboratories must integrate clinical information with coagulation testing for diagnostic accuracy.
  • Standardized protocols are needed to mitigate pre-analytical errors and drug interferences.
  • Improved understanding of drug-test interactions enhances patient safety and therapeutic monitoring.