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Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
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Substituent effects in Ugi-smiles reactions

Nicolas Chéron1, Romain Ramozzi, Laurent El Kaïm

  • 1Ecole Normale Supérieure de Lyon, Laboratoire de Chimie, Université de Lyon, UMR 5182, 46 allée d'Italie, F-69364 Lyon Cedex 07, France.

The Journal of Physical Chemistry. A
|July 27, 2013
PubMed
Summary

This study details the Ugi-Smiles coupling mechanism by analyzing reactant effects on the energy profile. Carbonyl compounds influence aryl-imidate formation, while amines affect the Smiles rearrangement, providing insights into reaction variations.

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