Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Properties of Organometallic Compounds

Properties of Organometallic Compounds

Organometallic compounds are compounds that contain a carbon–metal bond. Carbon belongs to an organyl group like alkyl, aryl, allyl, or benzyl groups. The metal can be from Group I or Group II of the periodic table, a transition metal, or a semimetal.

Introduction to Functional Groups

Introduction to Functional Groups

Functional groups are group of atoms with specific chemical properties that occur within organic molecules and sometimes denoted as “R”. Functional groups are found along the carbon backbone of macromolecules can form chains or rings of carbon atoms. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of common functional groups
The table below summarizes some of the major functional groups in organic chemistry. (The...

Overview of Advanced Functional Groups

Overview of Advanced Functional Groups

Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.

Functional Groups

Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...

Functional Groups

Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...

Functional Groups

Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pore Geometry-Driven Capture of Trace Aromatic Volatile Organic Compounds in Al-Based MOFs.

ACS nano·2026

Same author

Metal-Organic Framework as a Bioorthogonal Catalyst for Gene Editing.

Journal of the American Chemical Society·2026

Same author

Tunable Microporous Bimetallic Carboxylate-Pyrazolate Metal-Organic Frameworks for CO<sub>2</sub> Capture.

Journal of the American Chemical Society·2026

Same author

Framework-templated gas lattices in metal-organic frameworks.

Nature communications·2026

Same author

A Resonant Life.

Annual review of chemical and biomolecular engineering·2026

Same author

Geometric phase detection via NMR interferometry.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026

Search research articles

Related Experiment Video

Updated: May 9, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Mapping of functional groups in metal-organic frameworks.

Xueqian Kong¹, Hexiang Deng, Fangyong Yan

¹Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720, USA.

Science (New York, N.Y.)

|July 27, 2013

Summary

Researchers mapped functional group arrangements in multivariate metal-organic frameworks (MTV-MOFs) using NMR and simulations. This reveals patterns like random, alternating, and clustered distributions, aiding in predicting material properties.

More Related Videos

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

Published on: April 28, 2023

Related Experiment Videos

Last Updated: May 9, 2026

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Synthesis and Characterization of Functionalized Metal-organic Frameworks

Published on: September 5, 2014

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers

Published on: May 12, 2023

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

A Technical Guide for Performing Spectroscopic Measurements on Metal-Organic Frameworks

Published on: April 28, 2023

Area of Science:

Materials Science
Chemistry
Crystallography

Background:

Metal-organic frameworks (MOFs) are versatile porous materials with tunable properties.
Understanding the spatial arrangement of functional groups in multivariate MOFs (MTV-MOFs) is crucial for controlling their performance.
Existing methods often struggle to precisely determine heterogeneous functional group distributions at the mesoscale.

Purpose of the Study:

To determine the heterogeneous mesoscale spatial apportionment of functional groups in MTV-MOF-5.
To correlate functional group distribution with adsorptive properties.
To establish a methodology for analyzing spatial disorder in ordered materials.

Main Methods:

Utilized solid-state nuclear magnetic resonance (NMR) spectroscopy.
Employed molecular simulations to analyze functional group arrangements.
Synthesized and characterized MTV-MOF-5 with various functionalized 1,4-benzenedicarboxylate (BDC) linkers (BDC-NH2, BDC-NO2, BDC-(CH3)2, BDC-(OC3H5)2, BDC-(OC7H7)2).

Main Results:

Successfully discerned between random (e.g., BDC-NH2/BDC-NO2), alternating (e.g., BDC-NH2/BDC-NO2/BDC-(OC3H5)2), and clustered (e.g., BDC-NH2/BDC-(CH3)2) functional group apportionments.
Demonstrated the predictive power of the combined approach for adsorptive properties of crystalline MTV-MOF systems.
Validated the ability of NMR and simulations to resolve mesoscale spatial heterogeneity.

Conclusions:

The integrated NMR and computational approach provides precise insights into functional group ordering in MTV-MOFs.
This methodology enables prediction of material properties based on determined spatial arrangements.
The developed technique serves as a foundational step for addressing spatial disorder in broader material classes.