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Related Concept Videos

Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not related to...
Hepatic Portal System01:21

Hepatic Portal System

The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is responsible...

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Related Experiment Video

Updated: May 9, 2026

Intraoperative Video Consultation Following Bile Duct Transection Facilitates Direct OR Transfer for Robotic Hepaticojejunostomy at Tertiary Center
07:48

Intraoperative Video Consultation Following Bile Duct Transection Facilitates Direct OR Transfer for Robotic Hepaticojejunostomy at Tertiary Center

Published on: January 9, 2026

[Hepatic dysfunction correction in patients with obturation jaundice].

B M Datsenko, T I Tamm, V B Borisenko

    Klinichna Khirurhiia
    |July 30, 2013
    PubMed
    Summary

    Timely treatment of obstructive jaundice using minimally invasive procedures and L-ornithine L-aspartate effectively corrects liver dysfunction. This approach improves outcomes for patients with hepatic dysfunction and cholestasis syndromes.

    Related Experiment Videos

    Last Updated: May 9, 2026

    Intraoperative Video Consultation Following Bile Duct Transection Facilitates Direct OR Transfer for Robotic Hepaticojejunostomy at Tertiary Center
    07:48

    Intraoperative Video Consultation Following Bile Duct Transection Facilitates Direct OR Transfer for Robotic Hepaticojejunostomy at Tertiary Center

    Published on: January 9, 2026

    Area of Science:

    • Gastroenterology and Hepatology
    • Surgical Gastroenterology

    Background:

    • Obturation jaundice syndrome often leads to significant hepatic dysfunction.
    • Cytolysis and cholestasis syndromes are key indicators of liver injury severity.

    Purpose of the Study:

    • To analyze the effectiveness of miniinvasive interventions and subsequent hepatotropic therapy for obturation jaundice.
    • To evaluate the correction of hepatic dysfunction in patients with obstructive jaundice.

    Main Methods:

    • Comparative analysis of 54 patients with obturation jaundice syndrome.
    • Assessment of hepatic dysfunction using cytolysis and cholestasis indices.
    • Evaluation of severity based on V. P. Zinevich criteria (1986).
    • Treatment involved miniinvasive interventions and L-ornithine L-aspartate therapy.

    Main Results:

    • Miniinvasive interventions successfully eliminated obstructive jaundice.
    • Hepatotropic therapy with L-ornithine L-aspartate demonstrated effective correction of hepatic dysfunction.
    • The combined approach improved patient outcomes.

    Conclusions:

    • Early elimination of obstructive jaundice is crucial for managing hepatic dysfunction.
    • Complex hepatotropic therapy, particularly with L-ornithine L-aspartate, is effective in correcting liver dysfunction.
    • Miniinvasive interventions combined with targeted therapy offer a successful treatment strategy.