Related Experiment Video
Updated: Mar 20, 2026

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
Published on: May 31, 2024
[CHANGES OF HISTOSTRUCTURE OF CHRONIC ANAL FISSURE, DEPENDING ON DURATION OF THE DISEASE].
Histological analysis of chronic anal fissures (AF) reveals distinct inflammatory phases. Acute inflammation can last up to 7 months, transitioning to subacute and chronic cicatricial processes over time.
Area of Science:
- Gastroenterology
- Pathology
- Dermatology
Context:
- Chronic anal fissures (AF) represent a common anorectal condition.
- Understanding the histological timeline of AF is crucial for effective treatment strategies.
Purpose:
- To histologically characterize the inflammatory and cicatricial changes in chronic anal fissures.
- To establish a timeline for the progression of inflammation in AF based on histological findings.
Summary:
- Histological examination of 95 chronic anal fissure (AF) cases analyzed inflammatory signs and tissue presence.
- Acute inflammation in AF can persist up to 6-7 months.
- Subacute inflammation occurs from 8-11 months, with chronic cicatricial processes observed after 12 months.
Impact:
- Provides a histological basis for classifying AF chronicity.
- Informs clinical decision-making for managing anal fissure treatment.
- Contributes to understanding the natural history of chronic anal fissures.
More Related Videos
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
07:38Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
Published on: September 13, 2016
Related Concept Videos
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Assessment of the Rectum and Anus
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Histology of the Large Intestine
The innermost mucosa layer comprises simple columnar epithelium, lamina propria, and muscularis mucosae. This layer is primarily populated with absorptive cells, tasked with water absorption, and goblet cells, responsible for secreting mucus to...
Histology of the Small Intestine
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...