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[Vibratory and cooling detection thresholds in diabetes mellitus]
1Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
Journal of UOEH
|June 1, 1990
Summary
Diabetic neuropathy affects nerve fibers differently. Measuring both vibratory and cooling detection thresholds (VDT and CDT) helps evaluate the neuropathic state in patients with diabetes mellitus.
Area of Science:
- Neurology
- Diabetology
Context:
- Diabetes mellitus (NIDDM) frequently leads to peripheral neuropathy.
- Early detection of neuropathy is crucial for managing diabetic complications.
Purpose:
- To analyze the frequency of vibratory detection threshold (VDT) and cooling detection threshold (CDT) abnormalities in diabetic patients.
- To investigate the relationship between VDT/CDT and clinical/laboratory findings in NIDDM patients.
Summary:
- VDT and CDT were assessed in the upper and lower limbs of 53 NIDDM patients.
- Lower limb VDT correlated with age, diabetes duration, and blood urea nitrogen, but not glucose or HbA1c.
- Abnormalities in VDT and CDT suggest distinct peripheral nerve fiber involvement, aiding neuropathy evaluation.
Impact:
- 45% of patients exhibited abnormal VDT or CDT.
- VDT and CDT abnormalities were linked to subjective sensory disturbances, peripheral neuropathy, retinopathy, and proteinuria.
- Assessing both VDT and CDT provides a comprehensive evaluation of diabetic neuropathic states.