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What is the Cell Cycle?

The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
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Updated: May 9, 2026

Synchronization of Caulobacter Crescentus for Investigation of the Bacterial Cell Cycle
08:02

Synchronization of Caulobacter Crescentus for Investigation of the Bacterial Cell Cycle

Published on: April 8, 2015

The cell cycle of archaea.

Ann-Christin Lindås1, Rolf Bernander

  • 1Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Svante Arrhenius väg 20C, SE-106 91, Stockholm, Sweden.

Nature Reviews. Microbiology
|July 30, 2013
PubMed
Summary

Recent discoveries reveal the archaeal cell cycle involves multiple DNA replication origins, unique genome segregation, and novel cell division. The first archaeal cytoskeletal protein, crenactin, also impacts cell shape determination in organisms like Sulfolobus.

Area of Science:

  • Microbiology and Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular processes like growth, proliferation, and shape determination rely on regulated chromosome replication, genome segregation, and cell division.
  • Archaea, a distinct domain of life, possess unique cellular mechanisms that are increasingly being elucidated.
  • Understanding the archaeal cell cycle and cytoskeleton provides insights into fundamental biological processes.

Purpose of the Study:

  • To summarize current knowledge of the archaeal cell cycle and cytoskeleton.
  • To highlight recent advancements in understanding DNA replication, genome segregation, and cell division in archaea.
  • To focus on the genus Sulfolobus and identify key areas for future research.

Main Methods:

  • Review of recent scientific literature on archaeal cell cycle and cytoskeleton.

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  • Analysis of findings related to DNA replication origins, genome segregation machinery, and cell division systems.
  • Examination of the characterization and function of crenactin, the first identified archaeal cytoskeletal protein.

    • Main Results:

    • Archaea exhibit a multiple-origin mode of DNA replication.
    • Initial characterization of archaeal genome segregation machinery has been achieved.
    • A novel cell division system in archaea has been discovered.
    • The first archaeal cytoskeletal protein, crenactin, has been identified and its role in cell shape determination established.

    Conclusions:

    • Significant progress has been made in understanding the archaeal cell cycle and cytoskeleton, particularly in Sulfolobus species.
    • Outstanding questions remain regarding the intricate regulation and coordination of these fundamental cellular processes in archaea.
    • Further research is needed to fully unravel the complexities of archaeal cell biology.