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ASRDb: A comprehensive resource for archaeal stress response genes
Rajendra Kumar Labala1, Santasabuj Das, Surajit Basak
1Biomedical Informatics Center, National Institute of Cholera and Enteric Diseases, P-33, C.I.T Road, Scheme-XM, Beliaghata, Kolkata-700010, India.
Bioinformation
|August 2, 2013
Summary
The Archaeal Stress Response Database (ASRDb) is the first comprehensive online resource cataloging nearly 6000 stress-response genes from 66 archaeal genomes. This database aids in understanding microbial adaptation to extreme environments.
Area of Science:
- Microbiology
- Bioinformatics
- Genomics
Background:
- Organisms must sense and respond to environmental changes for survival.
- Archaea, thriving in extreme conditions, are valuable models for studying stress responses.
- Existing research lacks an integrated classification of archaeal stress responses.
Purpose of the Study:
- To develop the first comprehensive, web-accessible database of archaeal stress response genes.
- To classify and organize stress-specific genes from multiple archaeal genomes.
- To facilitate research into microbial adaptation mechanisms in extreme environments.
Main Methods:
- Compilation of stress-specific genes from 66 archaeal genomes.
- Development of a web-accessible database (ASRDb) with a user-friendly interface.
- Integration of query tools, advanced search options, and BLAST functionality.
Main Results:
- ASRDb contains nearly 6000 stress-specific genes from 66 archaeal genomes.
- Genes are categorized into 17 distinct stress types.
- The database offers efficient search capabilities and sequence retrieval.
Conclusions:
- ASRDb is a unique resource for studying archaeal adaptation to environmental stresses.
- The database will assist life scientists in unraveling the roles of stress-specific genes.
- Facilitates understanding of microbial survival strategies in extreme conditions.
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