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Updated: May 9, 2026

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
[Nosocomial viral infections. Hepatitis, herpes and flu viruses]
José Antonio Martinez1, Tomàs Pumarola
1Servicio de Enfermedades Infecciosas, Hospital Clínic, Barcelona, España.
Abstract:
Viruses account for about 5% of all nosocomial infections. Viral cross-infection is most common in infants and children, but also occurs in other groups, including the elderly, institutionalized persons of all ages, immunecompromised hosts, and patients with underlying chronic pulmonary, renal, or cardiac disease. These infections are associated with extended length of hospital stay, as well as considerable morbidity and mortality. The new technology of rapid viral diagnosis allows a more timely and accurate recognition of viral infections, even in the smaller hospital with limited laboratory resources. Early recognition of viral diseases should, in turn, permit the introduction, and further evaluation of specific measures for their control. Influenza vaccination of health care workers is an important prevention strategy for nosocomial infection.
Insights
Nosocomial viral infections, common in children and vulnerable adults, prolong hospital stays and increase mortality. Rapid viral diagnosis and influenza vaccination of healthcare workers are key strategies for control.
Area of Science:
- Infectious Diseases
- Hospital Epidemiology
- Virology
Context:
- Viruses cause approximately 5% of hospital-acquired infections.
- Viral cross-infection affects various patient groups, including pediatric, elderly, immunocompromised, and chronically ill individuals.
- These infections lead to prolonged hospital stays, increased morbidity, and mortality.
Purpose:
- To highlight the significance of viral nosocomial infections.
- To emphasize the role of rapid viral diagnostic technology.
- To underscore the importance of early recognition and control measures for viral diseases.
Summary:
- Rapid viral diagnosis enables timely and accurate identification of viral infections, even in resource-limited settings.
- Early detection facilitates the implementation and evaluation of specific control strategies.
- Influenza vaccination for healthcare workers is identified as a crucial prevention measure.
Impact:
- Improved patient outcomes through timely diagnosis and intervention.
- Reduced healthcare costs associated with extended hospital stays.
- Enhanced hospital infection control protocols and public health strategies.
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