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Structural determinants regulating cell surface targeting of melanocortin receptors

A R Rodrigues1, D Sousa, H Almeida

  • 1Department of Experimental Biology, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal Instituto de Biologia Molecular e Celular (IBMC), University of Porto, Porto, Portugal IPATIMUP, Institute of Molecular Pathology and Immunology Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal.

Journal of Molecular Endocrinology
|August 3, 2013
PubMed
Summary

Melanocortin receptors (MCRs) require specific structural motifs and accessory proteins for proper cell surface expression. Pharmacological stabilization of mutant MCRs offers a promising therapeutic approach for related diseases.

Keywords:
anterograde transportcell surfacemelanocortin receptorstargeting domains

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