Related Experiment Video

Updated: Aug 15, 2026

Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging
09:06

Labeling hESCs and hMSCs with Iron Oxide Nanoparticles for Non-Invasive in vivo Tracking with MR Imaging

Published on: March 31, 2008

Mn (III) hematoporphyrin. A potential MR contrast agent

P J Bohdiewicz1, D K Lavallee, R A Fawwaz

  • 1Department of Radiology, Columbia-Presbyterian Medical Center, New York, NY 10032.

Investigative Radiology
|July 1, 1990
PubMed

Insights

Manganese (III) hematoporphyrin (MnHP) shows potential as a liver MR contrast agent. While toxic at higher doses, MnHP demonstrated good in vivo stability and enhanced liver signal intensity in MR imaging.

Area of Science:

  • Biochemistry
  • Medical Imaging
  • Toxicology

Background:

  • Manganese (III) hematoporphyrin (MnHP) is a novel complex.
  • Its stability, toxicity, and utility in magnetic resonance (MR) imaging require evaluation.

Purpose of the Study:

  • To assess the toxicity profile of MnHP.
  • To evaluate the MR imaging properties of MnHP, particularly for liver applications.

Main Methods:

  • Acute and subacute toxicity tests were performed using intravenous injections of MnHP in rats.
  • In vivo stability was assessed using ultraviolet-visible spectroscopy.
  • MR imaging was conducted on rats injected with MnHP to measure liver-to-muscle intensity ratios and observe signal changes.

Main Results:

  • No mortality was observed at doses of 13 or 19 mumols/kg, but 33% mortality occurred at 38 mumols/kg.
  • Spectroscopy confirmed the in vivo stability of MnHP, with no free hematoporphyrin detected.
  • A significant increase (37%) in liver-to-muscle intensity ratios was observed at 25 mumols/kg, with visual enhancement of liver signal on T1-weighted images at lower doses.

Conclusions:

  • MnHP exhibits dose-dependent toxicity.
  • The complex is stable in vivo.
  • MnHP shows promise as an MR contrast agent for liver imaging, warranting further investigation.

More Related Videos

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications11:28

Biofunctionalized Prussian Blue Nanoparticles for Multimodal Molecular Imaging Applications

Published on: April 28, 2015

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Published on: November 20, 2018

Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Imaging Studies for Cardiovascular System IV: CMRI01:21

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...