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Updated: May 9, 2026
Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Focal segmental glomerulosclerosis in children: multivariate analysis indicates that donor type does not alter
Edward J Nehus1, Jens W Goebel, Paul S Succop
11 Division of Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. 2 Division of Epidemiology & Biostatistics, University of Cincinnati, Cincinnati, OH. 3 Department of Pediatrics, Saint Louis University at Cardinal Glennon Children's Medical Center, St. Louis, MO. 4 Address correspondence to: Elizabeth C. Abraham, M.D., M.S., Division of Nephrology, SSM Cardinal Glennon Children's Medical Center, 1465 South Grand Boulevard, St. Louis, MO 63104.
Focal segmental glomerulosclerosis (FSGS) is increasing in children needing kidney transplants. While young, white children have higher recurrence, living donor kidneys do not independently increase risk.
Area of Science:
- Pediatric Nephrology
- Transplantation Immunology
- Renal Pathology
Background:
- Focal segmental glomerulosclerosis (FSGS) is a growing cause of pediatric end-stage renal disease.
- Post-transplant FSGS recurrence is a significant clinical challenge.
- Concerns exist regarding increased recurrence risk in pediatric kidney recipients from living donors (LD).
Purpose of the Study:
- To analyze trends in kidney transplantation for FSGS in children.
- To identify risk factors associated with FSGS recurrence post-transplantation.
- To evaluate the impact of donor type on recurrence rates.
Main Methods:
- Analysis of United Network for Organ Sharing data (1988-2008) for pediatric FSGS kidney transplant recipients (ages 1-20).
- Poisson regression for trend analysis.
- Univariate and multivariable logistic regression to assess associations with recurrence (gender, race, HLA matching, age, donor type).
Main Results:
- Kidney transplantations for pediatric FSGS increased by 5.8% annually (209% over 20 years).
- Overall recurrence rate was 15% (327/2157 cases), higher in white recipients and younger age subgroups.
- Young age and white race were significant risk factors for recurrence; LD kidney donation was not independently associated with increased risk.
Conclusions:
- FSGS is an increasing indication for pediatric kidney transplantation.
- Young age and white race are key risk factors for FSGS recurrence.
- Living donor kidney transplantation is not an independent risk factor for increased FSGS recurrence.
