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Related Concept Videos

Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
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Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

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Introduction to Hemostasis01:05

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Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
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Disseminated intravascular coagulation.

Nazli Hossain1, Michael J Paidas

  • 1Department of Obstetrics & Gynecology, Dow University of Health Sciences, Karachi, Pakistan.

Seminars in Perinatology
|August 7, 2013
PubMed
Summary
This summary is machine-generated.

Disseminated intravascular coagulation (DIC) in obstetrics, linked to hemorrhage and other factors, causes high maternal and perinatal mortality. Management focuses on identifying the root cause of obstetric DIC.

Keywords:
CoagulationDisseminated intravascular coagulationObstetricsPregnancy

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Area of Science:

  • Obstetrics
  • Hematology
  • Pathophysiology

Background:

  • Disseminated intravascular coagulation (DIC) in obstetrics frequently accompanies massive hemorrhage from various etiological factors.
  • It is also associated with intrauterine demise, infections, and hepatic conditions, leading to significant maternal and perinatal morbidity and mortality.

Purpose of the Study:

  • To explore the molecular basis of obstetric DIC.
  • To identify key laboratory tests for diagnosis and management strategies.
  • To highlight areas for future research in obstetric DIC.

Main Methods:

  • Review of literature on obstetric DIC.
  • Analysis of diagnostic laboratory tests (prothrombin time, partial thromboplastin time, thrombin time, plasma fibrinogen).
  • Discussion of management principles centered on underlying pathology.

Main Results:

  • No single laboratory test is sufficiently sensitive or specific for diagnosing obstetric DIC.
  • Effective management hinges on identifying and addressing the primary cause of the coagulopathy.

Conclusions:

  • Obstetric DIC is a complex condition with severe consequences.
  • A multi-faceted approach involving molecular understanding, appropriate laboratory testing, and targeted management is crucial.
  • Further research is needed to improve outcomes for obstetric DIC.