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Trace elements and complications in patients undergoing chronic hemodialysis
S Hosokawa1, A Oyamaguchi, O Yoshida
1Utano National Hospital, Kyoto, Japan.
Insights
Trace element imbalances, including high aluminum and silicon, are common in chronic hemodialysis patients, potentially worsening anemia and bone disease. Regulating these minerals is crucial for preventing complications.
Area of Science:
- Nephrology
- Clinical Chemistry
- Trace Element Research
Background:
- Chronic hemodialysis (HD) patients often exhibit abnormal trace element levels.
- Trace element imbalances are suspected to contribute to various HD complications.
Purpose of the Study:
- To investigate the relationship between serum trace element concentrations and complications in chronic HD patients.
- To identify specific trace elements linked to anemia, bone disease, neurological disorders, and nutritional issues.
Main Methods:
- Serum concentrations of aluminum (Al), silicon (Si), zinc (Zn), manganese (Mn), and nickel (Ni) were measured in 100 chronic HD patients.
- Correlations were analyzed between trace element levels and clinical indicators of anemia (RBC, hemoglobin, hematocrit), bone disease, neurological disorder, and nutritional status.
Main Results:
- Serum Al and Si levels were significantly elevated in HD patients and negatively correlated with anemia indicators.
- High serum Al and Si levels were associated with peripheral neurological disorders and bone disease.
- Serum Zn, Mn, and Ni levels were found to be low and correlated with total serum protein.
Conclusions:
- Abnormalities in trace elements like Al, Si, Zn, Mn, and Ni are prevalent in chronic HD patients.
- Elevated Al and Si levels are linked to anemia and bone disease, while low Zn, Mn, and Ni correlate with protein levels.
- Monitoring and regulating trace element levels are essential for managing and preventing complications in chronic HD patients.
Abstract:
Abnormalities of trace elements such as aluminum, silicon, zinc, manganese and nickel were found in chronic hemodialysis (HD) patients. The relationship between serum concentration of trace elements and complications such as anemia bone disease, neurological disorder and nutritional disorder in 100 chronic HD patients was examined. Serum Al and Si levels were very high in these patients, and were negatively correlated with indicators of anemia such as RBC, hemoglobin and hematocrit values. Serum Al and Si levels in the HD patients with peripheral neurological disorder (excluding encephalopathy) and with bone disease were significantly high. The levels of serum Zn, Mn and Ni were low, and were correlated with total serum protein levels. In summary, in order to prevent some complications in chronic HD patients, it is very important to regulate levels of trace elements.