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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

Antimicrobial stewardship programs.

Kimberly D Leuthner¹, Gary V Doern

¹University Medical Center of Southern Nevada, Las Vegas, Nevada, USA.

Journal of Clinical Microbiology

|August 9, 2013

Summary

Antimicrobial resistance presents challenges in treating infections. Antimicrobial stewardship is crucial for optimizing the use of existing antimicrobial agents to combat difficult-to-treat infections.

Area of Science:

Medicine
Infectious Diseases
Pharmacology

Background:

Antimicrobial agents are a cornerstone of modern medicine.
The rise of antimicrobial resistance and a decline in new drug development create significant challenges.
Effective management of infections is increasingly difficult.

Purpose of the Study:

To introduce and define the concept of antimicrobial stewardship.
To highlight the importance of optimizing antimicrobial use in clinical practice.
To address the challenges posed by antimicrobial resistance.

Main Methods:

This minireview synthesizes current knowledge on antimicrobial resistance and stewardship.
It examines the critical need for judicious antimicrobial use.

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Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance

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Literature review and conceptual analysis form the basis of this work.

Main Results:

Antimicrobial resistance is a growing global health threat.
There is a pressing need for strategies to preserve the efficacy of current antimicrobials.
Antimicrobial stewardship is essential for combating resistant infections.

Conclusions:

Antimicrobial stewardship is vital for the effective management of infections.
Optimizing the use of existing antimicrobial resources is paramount.
This approach is critical in the face of increasing antimicrobial resistance.