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Topical nepafenac after intravitreal injection: a prospective double-masked randomized controlled trial
1Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina.
Retina (Philadelphia, Pa.)
|August 10, 2013
Summary
A single drop of nepafenac effectively reduced ocular discomfort following intravitreal injections. This study found nepafenac beneficial for managing post-injection pain, offering relief to patients.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Intravitreal injections are common procedures for retinal diseases.
- Ocular discomfort and pain are frequent side effects post-injection.
Purpose of the Study:
- To assess the efficacy of a single drop of nepafenac in alleviating ocular discomfort after intravitreal injections compared to a placebo.
Main Methods:
- A prospective, double-masked, randomized controlled trial was conducted.
- 120 patients received either nepafenac or placebo (Systane Ultra) post-injection.
- Pain was self-rated on a 0-3 scale at 1, 6, and 24 hours.
Main Results:
- Nepafenac showed a statistically significant reduction in pain at 6 hours post-injection (P < 0.001).
- Trends suggested pain reduction at 1 and 24 hours, though not statistically significant.
- Mean pain scores at 6 hours were 0.8 ± 0.6 for nepafenac vs. 1.3 ± 0.8 for placebo.
Conclusions:
- A single topical dose of nepafenac is effective in reducing post-intravitreal injection discomfort.
- Nepafenac offers a potential therapeutic option for managing pain after intravitreal procedures.
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