Related Experiment Video

Updated: May 8, 2026

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
09:14

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Published on: April 5, 2016

Clinical trials for the treatment of spinal cord injury: not so simple

Alan Mackay-Sim1, François Féron

  • 1National Centre for Adult Stem Cell Research, Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD, Australia.

Methods in Molecular Biology (Clifton, N.J.)
|August 13, 2013
PubMed

More Related Videos

A Contusion Model of Severe Spinal Cord Injury in Rats10:00

A Contusion Model of Severe Spinal Cord Injury in Rats

Published on: August 17, 2013

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery05:13

Development of Combinatorial Therapeutics for Spinal Cord Injury using Stem Cell Delivery

Published on: June 7, 2024

Related Concept Videos

Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...