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Growing Protein Crystals with Distinct Dimensions Using Automated Crystallization Coupled with In Situ Dynamic Light Scattering
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Effect of binder liquid type on spherical crystallization.

Maryam Maghsoodi1, Ali Hajipour

  • 1School of Pharmacy and Drug Applied Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.

Drug Development and Industrial Pharmacy
|August 14, 2013
PubMed
Summary

Selecting the right binder liquid solvent is key for successful spherical crystallization. This study shows how solvent properties influence crystal agglomerate formation and their final characteristics.

Keywords:
Binder liquidcarbamazepinespherical crystallization

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Area of Science:

  • Pharmaceutical Sciences
  • Chemical Engineering

Background:

  • Spherical crystallization is a method for forming crystal agglomerates using a binder liquid.
  • Understanding binder liquid properties is crucial for controlling agglomerate formation.

Purpose of the Study:

  • To investigate the impact of various solvents as binder liquids on crystal agglomeration.
  • To correlate binder liquid physical properties with agglomerate characteristics.

Main Methods:

  • Carbamazepine and ethanol/water were used as the model drug and crystallization system.
  • Eight different solvents were tested as binder liquids.
  • Agglomerates were evaluated for size, apparent particle density, and compressive strength.

Main Results:

  • Agglomerate formation showed a clear trend related to binder liquid physical properties, particularly miscibility.
  • The size, apparent particle density, and compressive strength of agglomerates were directly influenced by the binder liquid's properties.

Conclusions:

  • Binder liquid selection significantly impacts spherical crystallization outcomes.
  • This research provides a framework for choosing appropriate solvent systems for spherical crystallization.