Advanced multi-contrast Jones matrix optical coherence tomography for Doppler and polarization sensitive imaging

Area of Science:

• Ophthalmic imaging
• Biomedical optics
• Medical physics

Background:

• Jones matrix optical coherence tomography (JMT) is crucial for analyzing ocular tissues.
• Previous JMT versions had limitations in depth range and calibration.
• Doppler and polarization-sensitive imaging are vital for diagnosing posterior eye conditions.

Purpose of the Study:

• To demonstrate an advanced JMT system for enhanced Doppler and polarization-sensitive imaging of the posterior eye.
• To improve depth measurement range and system stability for clinical applications.
• To present a new theoretical framework integrating JMT, Doppler, and scattering measurements.

Main Methods:

• Development of an advanced JMT system utilizing incident polarization multiplexing with passive optical components.
• Implementation of a fine spectral shift compensation method for phase stabilization in OCT.
• Integration of Jones matrix, Doppler, and scattering measurements into a unified theoretical model.

Main Results:

• The advanced JMT system provides stable, cost-effective, and easily calibratable imaging.
• Achieved a significantly longer depth measurement range suitable for posterior eye diseases.
• Demonstrated high-sensitivity Doppler OCT and sensitivity-enhanced scattering OCT capabilities.
• Successfully performed in vivo imaging of choroidal vasculature and birefringence in healthy and diseased eyes.

Conclusions:

• The advanced JMT system offers a robust and versatile tool for ophthalmic diagnostics.
• The new theoretical framework enhances sensitivity for scattering and Doppler OCT.
• This technology holds significant potential for clinical applications in posterior eye disease diagnosis and research.