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Oxidized low-density lipoprotein and C-reactive protein have combined utility for better predicting prognosis after

Ya-chen Zhang1, Yong Tang, Yu Chen

  • 1Division of Cardiology, Xinhua Hospital School of Medicine, Shanghai Jiaotong University, 1665 Kong Jiang Road, Shanghai, 200092, China, zhangyachen1965@163.com.

Cell Biochemistry and Biophysics
|August 15, 2013
PubMed

Insights

Elevated oxidized low-density lipoprotein (Ox-LDL) and high-sensitivity C-reactive protein (hs-CRP) predict cardiovascular events in acute coronary syndrome (ACS) patients. Combining Ox-LDL and hs-CRP offers the strongest prediction for major adverse cardiovascular events.

Area of Science:

  • Cardiology
  • Biomarkers
  • Clinical Research

Background:

  • Elevated oxidized low-density lipoprotein (Ox-LDL) and high-sensitivity C-reactive protein (hs-CRP) are known predictors of cardiovascular events in acute coronary syndrome (ACS) patients.
  • The combined predictive value of Ox-LDL and hs-CRP for cardiovascular events in ACS patients remains underexplored.

Purpose of the Study:

  • To investigate the combined predictive value of Ox-LDL and hs-CRP for cardiovascular events in ACS patients.
  • To compare the predictive performance of Ox-LDL and hs-CRP, individually and combined, against cardiac troponin T (cTnT).

Main Methods:

  • A prospective cohort study involving 425 ACS patients followed for 3-5 years.
  • Serum concentrations of Ox-LDL, hs-CRP, and cTnT were measured at baseline.
  • Kaplan-Meier survival analysis and receiver-operating characteristic (ROC) curve analysis were used to assess predictive values.

Main Results:

  • 124 out of 425 patients experienced major adverse cardiovascular events (acute myocardial infarction or death).
  • Baseline Ox-LDL, hs-CRP, and cTnT levels were significantly higher in patients who experienced events.
  • Combined assessment of Ox-LDL and hs-CRP demonstrated the strongest risk prediction, outperforming individual markers and cTnT (AUCs: Ox-LDL 0.891, hs-CRP 0.834, cTnT 0.626).

Conclusions:

  • Elevated Ox-LDL and hs-CRP levels are significant predictors of cardiovascular events post-ACS.
  • The combined use of Ox-LDL and hs-CRP provides superior prognostic value for cardiovascular events compared to individual markers or cTnT.
  • Combining Ox-LDL and hs-CRP may enhance the prediction of prognosis in ACS patients with high sensitivity and specificity.

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