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Updated: May 8, 2026
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A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
Published on: June 4, 2021
Association between two functional fibrinogen-related polymorphisms and ischemic stroke: a case-control study.
Jingjing Zhang1, Lihua Yu, Yanying Yin
1Department of Neurology, West China Hospital, Sichuan University , Chengdu, Sichuan Province, China .
Genetic Testing and Molecular Biomarkers
|August 16, 2013
Summary
The minor allele G of rs6050 increases ischemic stroke (IS) risk in the Chinese Han population, while minor allele A of rs1800790 and haplotype AA decrease IS susceptibility.
Area of Science:
- Genetics
- Neurology
- Cardiovascular Research
Background:
- Fibrinogen is crucial for hemostasis and thrombosis.
- Two single-nucleotide polymorphisms (SNPs), rs6050 and rs1800790, in fibrinogen genes are investigated for their association with ischemic stroke (IS).
- Existing research presents conflicting findings on the roles of these SNPs in IS development.
Purpose of the Study:
- To investigate the association between fibrinogen gene variants (rs6050 and rs1800790) and ischemic stroke (IS) risk.
- To determine the specific alleles and haplotypes conferring risk or protection against IS.
- To analyze these associations in the Chinese Han population.
Main Methods:
- Genotyping of 1402 subjects (834 IS cases, 568 controls) for SNPs rs6050 and rs1800790 using ligation detection reaction.
- Statistical analysis including odds ratios (OR) and confidence intervals (CI) for genotype and haplotype associations.
- Stratification analysis by IS subtypes: large-artery atherosclerosis and cardioembolism.
Main Results:
- The homozygous minor allele genotype (GG) of rs6050 significantly increased IS risk (OR=1.660).
- The homozygous minor allele genotype of rs1800790 significantly reduced IS risk (OR=0.413).
- Haplotype analysis revealed that haplotype AA (rs6050 major, rs1800790 minor) decreased IS susceptibility (OR=0.650).
Conclusions:
- Minor allele G at rs6050 is a significant risk factor for IS in the Chinese Han population.
- Minor allele A at rs1800790 and haplotype AA are protective factors against IS.
- These findings contribute to understanding the genetic basis of ischemic stroke.
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