Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Clinical Significance of Antibiotic Resistance

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...

Healthcare Associated Infections II: Preventive Measures

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents

Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...

Standard Precaution

Standard Precaution

Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Variety of <i>Clostridioides difficile</i> Ribotypes in CDI Patients in Las Vegas, NV.

Germs·2026

Same author

Clinical efficacy of dalbavancin for the treatment of acute bacterial skin and skin structure infections (ABSSSI).

Therapeutics and clinical risk management·2016

Same author

Dalbavancin (BI-387) for the treatment of complicated skin and skin structure infection.

Expert review of anti-infective therapy·2015

Same author

Antimicrobial stewardship programs.

Journal of clinical microbiology·2013

Same author

In vitro activity of the new multivalent glycopeptide-cephalosporin antibiotic TD-1792 against vancomycin-nonsusceptible Staphylococcus isolates.

Antimicrobial agents and chemotherapy·2010

Same author

An update and review of antiretroviral therapy.

Pharmacotherapy·2006

Search research articles

Related Experiment Video

Updated: May 8, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Antimicrobial stewardship and Clostridium difficile-associated diarrhea.

Frank J Piacenti¹, Kimberly D Leuthner

¹Department of Pharmacy, Lincoln Medical Center, Bronx, NY, USA.

Journal of Pharmacy Practice

|August 16, 2013

Summary

Antimicrobial stewardship programs are crucial for healthcare institutions to optimize antibiotic use, thereby reducing Clostridium difficile infections and combating antimicrobial resistance. These programs are vital for patient safety and public health.

Keywords:

Clostridium difficile antibiotic usage antimicrobial stewardship

More Related Videos

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Related Experiment Videos

Last Updated: May 8, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 14, 2013

Area of Science:

Infectious Diseases
Public Health
Health Policy

Background:

Clostridium difficile-associated diarrhea (CDAD) is a growing public health concern, posing a significant threat to patients receiving antibiotics.
Antibiotic use disrupts normal gut flora, leading to CDAD, which is more immediately dangerous than antimicrobial resistance.
Healthcare institutions require effective strategies to manage antibiotic use and prevent associated infections.

Purpose of the Study:

To review the impact of antimicrobial stewardship programs (ASPs) on Clostridium difficile infection (CDI) rates.
To discuss the design, implementation, monitoring, and follow-through of ASPs in healthcare settings.
To highlight the importance of ASPs in controlling hospital-associated infections.

Main Methods:

Literature review on the effects of ASPs on CDI rates.
Analysis of strategies employed by ASPs, including audit with feedback and antibiotic restriction.
Examination of components of ASPs such as guideline implementation, staff education, and infection control.

Main Results:

ASPs optimize antimicrobial selection, dosing, de-escalation, and duration of therapy.
Effective ASPs incorporate hospital-wide guidelines, staff education, and infection-control measures.
Electronic medical records can support antibiotic use control within ASPs.

Conclusions:

Antimicrobial stewardship programs are essential for decreasing Clostridium difficile rates in healthcare settings.
ASPs play a critical role in preventing infections and promoting appropriate antibiotic use.
Successful implementation and monitoring of ASPs are key to controlling hospital-associated infections.