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Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...

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Related Experiment Video

Updated: May 8, 2026

Determination of Inorganic Arsenic in a Wide Range of Food Matrices using Hydride Generation - Atomic Absorption Spectrometry.
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Published on: September 1, 2017

EURRECA-Estimating selenium requirements for deriving dietary reference values.

Rachel Hurst1, Rachel Collings, Linda J Harvey

  • 1Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, NR4 7TJ, UK.

Critical Reviews in Food Science and Nutrition
|August 20, 2013
PubMed
Summary
This summary is machine-generated.

Current selenium reference values are based on maximal enzyme activity. This review evaluates selenium status, health effects, bioavailability, and genetic factors to inform future dietary reference values.

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Published on: October 29, 2021

Related Experiment Videos

Last Updated: May 8, 2026

Determination of Inorganic Arsenic in a Wide Range of Food Matrices using Hydride Generation - Atomic Absorption Spectrometry.
08:21

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Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon
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Assessing Mineral Availability in Fish Feeds using Complementary Methods Demonstrated with the Example of Zinc in Atlantic Salmon

Published on: October 29, 2021

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Human Health

Background:

  • Dietary reference values for selenium are currently based on achieving maximal glutathione peroxidase activity.
  • Selenium is an essential micronutrient vital for various physiological processes.

Purpose of the Study:

  • To systematically review and evaluate evidence relevant to setting dietary reference values for selenium.
  • To assess selenium status biomarkers, health outcomes, bioavailability, and genetic influences.

Main Methods:

  • Systematic literature searches and review.
  • Evaluation of relationships between selenium intake and status biomarkers.
  • Assessment of selenium's impact on cancer risk, immune function, HIV, cognition, and fertility.
  • Analysis of selenium bioavailability and genotype/single nucleotide polymorphism effects.

Main Results:

  • The review synthesizes current knowledge on selenium status and its relationship with intake.
  • Evidence regarding selenium's influence on various health outcomes was evaluated.
  • Bioavailability of dietary selenium and the role of genetic factors were assessed.

Conclusions:

  • The EURRECA Network's findings provide a comprehensive overview of selenium research.
  • Identified research outputs and future priorities are crucial for refining selenium dietary reference values.