Copper-mediated direct C2-cyanation of indoles using acetonitrile as the cyanide source
Changduo Pan1, Hongming Jin, Pan Xu
1State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University , Nanjing 210093, P. R. China.
Abstract:
A copper-mediated C2-cyanation of indoles using cheap and commercially available acetonitrile as the "nonmetallic" cyanide source was achieved through sequential C-C and C-H bond cleavages. The installation of a removable pyrimidyl group on the indole nitrogen atom is the key for this C2 selectivity. This approach provides a novel and alternative route leading to indole-2-carbonitrile.
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