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Updated: May 8, 2026
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The Corneal Micropocket Assay: A Model of Angiogenesis in the Mouse Eye
Published on: August 16, 2014
[Imaging and quantification of corneal neovascularization].
Y Benayoun1, R Rosenberg, G Casse
1Service d'ophtalmologie, hôpital Dupuytren, CHU de Limoges, 2, avenue Martin-Luther-King, 87042 Limoges cedex 1, France; Service d'ophtalmologie, clinique François-Chénieux, 18, rue du Général-Catroux, 87039 Limoges cedex, France.
Journal Francais D'Ophtalmologie
|August 24, 2013
Summary
Corneal neovascularization, the growth of blood vessels into the cornea, impairs vision and transplant success. This review covers methods to document and quantify these neovessels to improve corneal transplantation outcomes.
Area of Science:
- Ophthalmology
- Vascular Biology
- Regenerative Medicine
Context:
- Corneal neovascularization (CNV) is the abnormal growth of blood vessels into the normally clear cornea.
- CNV results from tissue injury, reducing visual acuity and compromising corneal immune privilege.
- This impacts the success of corneal transplantation (keratoplasty).
Purpose:
- To review and present methods for documenting corneal neovascularization.
- To discuss techniques for classifying and quantifying corneal neovascularization.
- To establish a basis for comparing antiangiogenic therapies for CNV.
Summary:
- The review details various methods to visualize neovessels, including color photography, fluorescein angiography, indocyanine green angiography, and in vivo confocal microscopy.
- It further explores approaches to classify and quantify the extent of corneal neovascularization.
- These methods are crucial for evaluating the efficacy of treatments aimed at reducing CNV.
Impact:
- Accurate quantification of CNV is essential for comparing antiangiogenic drug efficacy.
- Improved understanding and measurement of CNV can enhance the success rates of corneal transplantation.
- This research supports the development of novel therapeutic strategies for corneal diseases.
