Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Applying a multi-task and multi-instance framework to predict axillary lymph node metastases in breast cancer.

NPJ precision oncology·2025

Same author

In(III)-catalyzed tandem reaction of chromone-derived Morita-Baylis-Hillman alcohols with amines.

Organic & biomolecular chemistry·2010

Same author

Regression-based multi-trait QTL mapping using a structural equation model.

Statistical applications in genetics and molecular biology·2010

Same author

Elevated expression of APE1/Ref-1 and its regulation on IL-6 and IL-8 in bone marrow stromal cells of multiple myeloma.

Clinical lymphoma, myeloma & leukemia·2010

Same author

Accelerated aging of intervertebral discs in a mouse model of progeria.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2010

Same author

The synthesis of a multiblock osteotropic polyrotaxane by copper(I)-catalyzed huisgen 1,3-dipolar cycloaddition.

Macromolecular bioscience·2010

Search research articles

Related Experiment Video

Updated: May 8, 2026

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Published on: April 13, 2012

A rapid automatic processing platform for bead label-assisted microarray analysis: application for genetic

Jiang Zhu¹, Xiumei Song, Guangxin Xiang

¹1CapitalBio Corporation, Beijing, P. R. China.

Journal of Laboratory Automation

|August 27, 2013

Summary

This summary is machine-generated.

This study introduces an automated microarray platform that significantly reduces processing time and manual steps in molecular diagnostics. This innovation enhances efficiency and reproducibility for clinical genetic testing.

Keywords:

automated platform microarray microfluidic chip mutation detection

More Related Videos

Competitive Genomic Screens of Barcoded Yeast Libraries

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Related Experiment Videos

Last Updated: May 8, 2026

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Fluorescence-microscopy Screening and Next-generation Sequencing: Useful Tools for the Identification of Genes Involved in Organelle Integrity

Published on: April 13, 2012

Competitive Genomic Screens of Barcoded Yeast Libraries

Competitive Genomic Screens of Barcoded Yeast Libraries

Published on: August 11, 2011

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations

Published on: November 3, 2010

Area of Science:

Molecular Diagnostics
Biotechnology
Genetics

Background:

Standard microarray processing is time-consuming and labor-intensive, involving manual steps.
High throughput, sensitivity, and accuracy of microarrays are valuable for clinical diagnosis.
Automation is needed to improve efficiency and reproducibility in molecular diagnostics.

Purpose of the Study:

To develop an integrated platform for automated microarray processing.
To significantly shorten processing time and improve reproducibility.
To demonstrate the utility of the automated platform in clinical settings.

Main Methods:

Development of an integrated platform incorporating a microfluidic chip, flow control, temperature control, imaging, and automated analysis.
Utilized bead labeling for microarray signals with continuous monitoring.
Applied the platform to genotype hereditary hearing-loss gene mutations.

Main Results:

The automated platform significantly reduced microarray processing time and manual steps.
Increased efficiency and reproducibility of hybridization and result analysis.
Continuous monitoring of signals facilitated optimization of processing conditions.

Conclusions:

The automated platform enhances efficiency and reproducibility in molecular genetic testing.
Its modular design supports simultaneous processing of multiple microfluidic chips.
The platform is beneficial for clinical settings requiring fast, low-complexity genetic testing.