Related Experiment Video
Updated: May 8, 2026

Evaluation of Drug Sorption to PVC- and Non-PVC-based Tubes in Administration Sets Using a Pump
Published on: March 11, 2017
Stability of levothyroxine sodium injection in polypropylene syringes
1Pharmaceutics Division, University of Houston, Houston, TX.
Abstract:
A stability-indicating high-performance liquid chromatography assay method was used to study the stability of levothyroxine sodium injection (100 micrograms/mL) in 0.9% sodium chloride injection after being stored at 5 deg C in polypropylene syringes. The method developed is accurate and precise and has a percent relative standard deviation of 1.3 based on 5 readings. The concentrations of the drug were directly related to the peak heights. The drug in the injection did not adsorb onto the polypropylene syringes. After 7 days of storage at 5 deg C, the injection was clear, the pH value had not changed, and there was no loss in the potency of levothyroxine sodium. The manufacturer's recommendation that the injection be used immediately after reconstitution is very conservative.
Related Concept Videos
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence
Drug Product Stability
RNA Stability
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Nonlinear Pharmacokinetics: Drug Elimination for IV Bolus Injection
Following the administration of a single intravenous (IV) bolus injection, we can determine the concentration of the drug in the plasma at any given time. This calculation is achieved using a specific equation that integrates the values of Vmax and KM.
We can also...
