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Related Experiment Video

Updated: May 8, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Recent insights into Clostridium difficile pathogenesis.

Alex G Peniche1, Tor C Savidge, Sara M Dann

  • 1Infectious Disease Division, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas 77555-0435, USA.

Current Opinion in Infectious Diseases
|August 29, 2013
PubMed
Summary
This summary is machine-generated.

Clostridium difficile infection (CDI) mechanisms are better understood through toxin action, microbial dysbiosis, and host immunity. Recent research highlights microbiome shifts and immune responses, paving the way for new CDI therapies.

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Related Experiment Videos

Last Updated: May 8, 2026

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
12:58

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Clostridium difficile infection (CDI) is a major cause of healthcare-associated diarrhea and colitis.
  • CDI pathogenesis involves pathogenic toxins, gut microbial imbalance (dysbiosis), and host inflammation.

Purpose of the Study:

  • To review and highlight recent advancements in understanding CDI pathogenic mechanisms.
  • To consolidate current knowledge on toxin action, microbial shifts, and host immune responses in CDI.

Main Methods:

  • Literature review of recent studies on CDI mechanisms.
  • Analysis of multiomic data related to microbiome dysbiosis.
  • Examination of host immune responses in CDI models.

Main Results:

  • New insights into toxin inhibition, spore germination, and surface protein function in CDI.
  • Identification of CDI-associated microbial community shifts and potential biomarkers.
  • Delineation of innate and adaptive immunity roles, including novel S-nitrosylation signals.

Conclusions:

  • Microbiota, metabolome, and host responses are critical in primary and recurrent CDI.
  • Understanding CDI pathogenesis is key to developing novel treatments and prevention strategies.
  • Future therapies may leverage microbiome modulation and targeted immunomodulation.