Related Experiment Video

Updated: May 8, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Etiology of valvular heart disease in the 21st century

Konstantinos Dean Boudoulas1, Jeffrey S Borer, Harisios Boudoulas

  • 1Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.

Cardiology
|August 31, 2013
PubMed

Insights

Valvular heart disease (VHD) causes have shifted significantly over 60 years. This review explores evolving VHD factors, current causes, and links to atherosclerosis and other organ systems.

Area of Science:

  • Cardiology
  • Medical Research

Background:

  • The causes of valvular heart disease (VHD) have undergone a significant transformation over the past six decades.
  • Understanding these changes is crucial for effective VHD management.

Purpose of the Study:

  • To review the factors contributing to the metamorphosis in VHD etiology.
  • To present the common causes of VHD today.
  • To explore the relationship between valvular calcification and atherosclerosis, and VHD's interrelationship with other organ systems.

Main Methods:

  • Literature review of studies on valvular heart disease etiology over the last 60 years.
  • Analysis of current etiological factors and common causes of VHD.
  • Examination of the connection between valvular calcification and atherosclerosis.
  • Investigation of systemic VHD interrelationships.

Main Results:

  • Etiology of VHD has shifted dramatically in recent decades.
  • Valvular calcification shares links with atherosclerosis.
  • VHD is interconnected with various other organ systems.

Conclusions:

  • The etiological landscape of VHD has evolved.
  • Awareness of current VHD causes and systemic links is essential for clinical practice and research.

More Related Videos

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve07:34

Surgery and Sample Processing for Correlative Imaging of the Murine Pulmonary Valve

Published on: August 5, 2021

Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System08:47

Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System

Published on: October 19, 2015

Related Concept Videos

Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Mitral Valve Prolapse I: Introduction01:27

Mitral Valve Prolapse I: Introduction

IntroductionThe mitral valve, one of the heart's four valves, regulates blood flow. These valves have flaps that open and close to direct blood properly through the heart and body. During each heartbeat, the flaps open for blood to pass through and seal shut to prevent backflow. Specifically, the mitral valve opens to allow blood flow from the heart's upper left chamber to the lower left chamber. It then closes securely as the lower left chamber contracts to pump blood to the body, preventing...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...