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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Maternal depression and infant development: theory and current evidence.
Lisa Miklush1, Cynthia D Connelly
1Lisa Miklush is an Assistant Professor, Gonzaga University, Spokane, WA. She can be reached via e-mail at miklush@gonzaga.edu Cynthia D. Connelly is Professor and Director of Nursing Research, University of San Diego, San Diego, CA.
MCN. the American Journal of Maternal Child Nursing
|August 31, 2013
Summary
Maternal depression (MD) negatively impacts infant development. Understanding the historical, theoretical, and biological links, including neuroendocrine and epigenetic factors, is crucial for effective nursing care and improved child outcomes.
Area of Science:
- Perinatal mental health
- Developmental psychology
- Neuroscience
Background:
- Maternal depression (MD) significantly affects maternal well-being, family dynamics, and societal health.
- Existing research indicates a strong association between maternal depression and adverse infant developmental trajectories.
- Understanding these links is vital for comprehensive perinatal care.
Purpose of the Study:
- To review the historical and theoretical foundations of the link between maternal depression and infant development.
- To explore the neuroendocrine and epigenetic mechanisms underlying the sequelae of maternal depression.
- To provide a foundation for evidence-based nursing interventions for families affected by maternal depression.
Main Methods:
- Literature review synthesizing historical perspectives.
- Theoretical framework analysis of maternal depression's impact on child development.
- Exploration of neuroendocrine and epigenetic research findings.
Main Results:
- Historical and theoretical frameworks support the link between maternal depression and infant developmental issues.
- Neuroendocrine pathways (e.g., HPA axis) and epigenetic modifications are implicated in mediating these effects.
- Early identification and intervention are critical for mitigating negative outcomes.
Conclusions:
- Maternal depression poses significant risks to infant development through various biological pathways.
- A comprehensive understanding of these pathways informs clinical practice and nursing care.
- Interventions targeting maternal mental health can positively influence infant developmental trajectories.
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