Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-Dose Brachytherapy for Choroidal Melanoma: A Preliminary Report.

Ophthalmology. Retina·2026
Same author

Metastatic Uveal Melanoma Surveillance: A Delphi Panel Consensus.

Cancers·2026
Same author

Ultrasound Biomicroscopy in the Diagnosis and Management of Iris and Ciliary Body Tumors: A Comprehensive Review.

Ocular oncology and pathology·2025
Same author

Early-stage ocular toxocariasis: Progression and histopathologic analysis.

American journal of ophthalmology case reports·2025
Same author

Unifying Diagnosis of Choroidal Indeterminate Melanocytic Tumors-Reply.

JAMA ophthalmology·2025
Same author

Suprachoroidal Injection of Topotecan for Retinoblastoma: A Preclinical Study.

Ophthalmology science·2025

Related Experiment Video

Updated: May 8, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Brachytherapy.

Gaurav Marwaha1, Roger Macklis, Arun D Singh

  • 1Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Developments in Ophthalmology
|August 31, 2013
PubMed
Summary

Brachytherapy, a targeted radiation therapy, is ideal for eye tumors like uveal melanoma. It precisely delivers radiation using episcleral plaques, minimizing damage to surrounding healthy eye structures.

Area of Science:

  • Ophthalmology
  • Radiation Oncology
  • Medical Physics

Background:

  • Brachytherapy is a primary treatment for intraocular tumors, particularly uveal melanoma.
  • It involves placing radioactive sources near the tumor using episcleral plaques.
  • This method offers precise radiation delivery with rapid dose fall-off, sparing critical structures.

Purpose of the Study:

  • To review the history and evolution of brachytherapy for intraocular tumors.
  • To detail current practices, including commonly used isotopes and plaque designs.
  • To provide a comprehensive overview of treatment planning and the physics involved.

Main Methods:

  • Historical review of brachytherapy techniques and sources.
  • Analysis of current clinical practices for intraocular brachytherapy.

More Related Videos

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

Related Experiment Videos

Last Updated: May 8, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

  • Discussion of radiation physics, dosimetry, and treatment planning principles.

    • Main Results:

    • Iodine-125 is the most frequently used radioactive source in current practice.
    • Episcleral plaques enable highly localized radiation delivery.
    • The sharp dose fall-off characteristic of brachytherapy is crucial for ocular tissue preservation.

    Conclusions:

    • Brachytherapy remains a cornerstone treatment for intraocular tumors due to its efficacy and precision.
    • Understanding the history, current methods, and physics is essential for optimal patient outcomes.
    • Continued advancements in isotopes and planning enhance the safety and effectiveness of ocular brachytherapy.