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Related Concept Videos

Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: May 8, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

Radiation therapy: uveal tumors.

Stefan Seregard1, David E Pelayes, Arun D Singh

  • 1St Eriks Eye Hospital, Karolinska Institutet, Stockholm, Sweden. stefan.seregard@sankterik.se

Developments in Ophthalmology
|August 31, 2013
PubMed
Summary

Uveal melanoma, a rare eye cancer, is increasingly treated with eye-preserving radiotherapy, improving patient quality of life. Early tumor detection is crucial for minimizing radiotherapy side effects and preserving vision.

Area of Science:

  • Ophthalmology
  • Oncology
  • Radiation Oncology

Background:

  • Uveal melanoma is the most common primary malignant tumor of the eye.
  • Historically treated with globe enucleation, modern approaches prioritize eye preservation.
  • Radiotherapy is a key component of eye-sparing management for uveal melanoma.

Purpose of the Study:

  • To review the current management of uveal melanoma with a focus on radiotherapy.
  • To discuss the benefits and challenges of eye-preserving treatments.
  • To highlight the importance of early detection in optimizing treatment outcomes.

Main Methods:

  • Review of radiotherapy techniques for uveal melanoma, including episcleral brachytherapy and teletherapy (charged particle irradiation, stereotactic radiotherapy/radiosurgery).

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  • Discussion of treatment side effects and complications.
  • Exploration of the application of uveal melanoma treatment experience to other ocular tumors.

    • Main Results:

    • Over 90% of preserved eyes utilize radiotherapy, predominantly episcleral brachytherapy.
    • Radiotherapy allows for vision preservation and improved quality of life, despite potential side effects.
    • Tumor size is directly related to radiotherapy complications, emphasizing the need for early detection.

    Conclusions:

    • Eye-preserving radiotherapy is a successful strategy for managing uveal melanoma.
    • Minimizing radiotherapy-related side effects requires early tumor detection and precise treatment planning.
    • Experience with uveal melanoma treatment informs management of other benign and malignant ocular tumors.