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Related Experiment Video

Updated: May 8, 2026

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy

Published on: January 22, 2018

Radiation therapy: anterior segment complications.

Carlos A Medina Mendez¹, Arun D Singh

¹Vitreoretinal Service, Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.

Developments in Ophthalmology

|August 31, 2013

Summary

Radiotherapy aims to maximize tumor damage while minimizing harm to surrounding tissues. This review details anterior chamber complications, ranging from irritation to blindness, and discusses their prevention and management.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

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Published on: January 22, 2018

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

Ophthalmology
Radiation Oncology

Background:

Radiotherapy is a cornerstone in cancer treatment, aiming for targeted tumor destruction.
Understanding ocular complications is crucial for patient care and treatment planning.

Purpose of the Study:

To comprehensively review anterior chamber complications following radiotherapy.
To categorize these complications into acute and chronic phases.
To outline prevention and management strategies based on affected ocular tissues.

Main Methods:

Literature review of anterior chamber complications from radiotherapy.
Classification of complications based on timing (acute/chronic) and affected ocular structures.
Synthesis of current knowledge on prevention and management.

Main Results:

Radiotherapy can cause a spectrum of anterior chamber complications, from mild ocular surface irritation to severe vision loss, including blindness.
Complications are categorized as acute (occurring within 4 weeks) or chronic (occurring after 4 weeks).
Specific management and prevention strategies are detailed for various affected ocular tissues.

Conclusions:

Anterior chamber complications are a significant concern in radiotherapy patients.
Timely recognition, prevention, and tailored management are essential to mitigate vision-threatening outcomes.
Further research into optimizing radiotherapy techniques to spare ocular tissues is warranted.