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Published on: March 8, 2013

Association between serum immunoglobulin G4 concentration and cardiac function among elderly cardiology inpatients

Kazushi Sakane1, Kensaku Shibata, Shu-ichi Fujita

  • 1Department of Cardiology, Osaka Medical College, Osaka, Japan.

Geriatrics & Gerontology International
|September 3, 2013
PubMed

Insights

Serum immunoglobulin G4 (IgG4) concentration is linked to diastolic cardiac function in elderly patients. This finding suggests IgG4 may play a role in heart health among older cardiology inpatients.

Area of Science:

  • Cardiology
  • Immunology
  • Geriatrics

Background:

  • Serum immunoglobulin G4 (IgG4) is an antibody isotype.
  • Cardiac function assessment is crucial in cardiology inpatients.
  • The relationship between IgG4 and cardiac function requires further investigation.

Purpose of the Study:

  • To investigate the association between serum IgG4 levels and cardiac function in cardiology inpatients.
  • To determine if this association differs between elderly and younger patients.

Main Methods:

  • Retrospective study of 91 cardiology inpatients with sinus rhythm.
  • Patients divided into elderly (≥60 years) and younger (<60 years) groups.
  • Serum IgG4 concentrations correlated with cardiac function parameters (BNP, E/e', left ventricular mass, ejection fraction).

Main Results:

  • Serum IgG4 negatively correlated with brain natriuretic peptide (BNP) and E/e' (diastolic function indicator) in the elderly group.
  • No significant correlation found between IgG4 and cardiac function parameters in the younger group.
  • Multivariate analysis confirmed the independent association of IgG4 with diastolic function markers in the elderly.

Conclusions:

  • Serum IgG4 concentration may be associated with cardiac diastolic function in elderly cardiology inpatients.
  • IgG4's role in cardiac health warrants further research, particularly in older populations.
Abstract

Keywords:
cardiac functiondiastolic functionheart failurehypertrophy

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