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Related Concept Videos

Genome Annotation and Assembly03:36

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Genomic DNA in Eukaryotes00:58

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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A Web-Based Workflow for Selecting Gene- and Tissue-Specific Enhancers
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Published on: July 18, 2025

Web Apollo: a web-based genomic annotation editing platform.

Eduardo Lee, Gregg A Helt, Justin T Reese

    Genome Biology
    |September 5, 2013
    PubMed
    Summary
    This summary is machine-generated.

    Web Apollo is a real-time, web-based genomic annotation editor enabling collaborative genome analysis. It empowers researchers to describe functional features of newly sequenced genomes efficiently, regardless of location.

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    A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes

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    Area of Science:

    • Genomics
    • Bioinformatics
    • Computational Biology

    Background:

    • Advances in sequencing technology are accelerating the generation of new genome data.
    • Researchers require efficient tools for annotating and describing the functional elements of these genomes.
    • Existing annotation tools may lack real-time collaborative capabilities.

    Purpose of the Study:

    • To introduce Web Apollo, a novel web-based platform for genomic annotation.
    • To provide an instantaneous and collaborative solution for genome feature description.
    • To support researchers in analyzing and annotating newly sequenced genomes.

    Main Methods:

    • Web Apollo is a web-based application accessible via common browsers.
    • It facilitates real-time, joint analysis and annotation of genomic data.
    • The platform supports collaborative efforts among researchers globally.

    Main Results:

    • Web Apollo offers the first instantaneous, collaborative genomic annotation editing experience online.
    • It enables researchers to jointly analyze and precisely describe genome features in real time.
    • The tool is accessible using standard web browsers like Chrome and Firefox.

    Conclusions:

    • Web Apollo addresses the need for efficient, collaborative genome annotation tools.
    • It enhances the process of describing functional features in newly sequenced genomes.
    • The platform facilitates global collaboration in genomic research.