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Updated: May 8, 2026

Synthesis and Structure Determination of µ-Conotoxin PIIIA Isomers with Different Disulfide Connectivities
Published on: October 2, 2018
Synthetic studies on hemicalide: development of a convergent approach toward the C1-C25 fragment
Geoffroy Sorin1, Etienne Fleury, Christine Tran
1Faculté de Pharmacie, Université Paris Descartes , CNRS UMR 8638, 4 avenue de l'observatoire, 75270 Paris Cedex 06, France, CNRS-Pierre Fabre USR 3388 , Centre de Recherche & Développement Pierre Fabre, 3 avenue Hubert Curien, 31035 Toulouse Cedex 01, France, and Laboratoire de Chimie Organique, ESPCI ParisTech , CNRS UMR 7084, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
Abstract:
Synthetic studies on hemicalide, a recently isolated marine natural product displaying highly potent antiproliferative activity and a unique mode of action, have highlighted a reliable Horner-Wadsworth-Emmons olefination to create the C6-C7 alkene and a remarkable efficient Suzuki-Miyaura coupling to form the C15-C16 bond, resulting in the development of a convergent approach toward the C1-C25 fragment.
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