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Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS
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Immunosuppressive drug therapy.

Choli Hartono1, Thangamani Muthukumar, Manikkam Suthanthiran

  • 1Division of Nephrology and Hypertension, Departments of Medicine and Transplantation Medicine, New York Presbyterian Hospital-Weill Cornell Medical College, New York, New York 10065.

Cold Spring Harbor Perspectives in Medicine
|September 5, 2013
PubMed
Summary
This summary is machine-generated.

Organ transplantation is a life-saving procedure, but requires immunosuppressive drugs to prevent rejection in genetically different recipients. Personalized therapy remains a challenge.

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Area of Science:

  • Immunology
  • Transplantation Medicine
  • Pharmacology

Background:

  • The first kidney transplant between identical twins succeeded without immunosuppression.
  • Organ transplantation is now a standard, life-saving treatment for organ failure.
  • Immunosuppressive drugs are crucial for transplants between genetically disparate individuals.

Purpose of the Study:

  • To review the evolution of immunosuppressive therapy in organ transplantation.
  • To highlight advancements in targeting specific immune pathways involved in rejection.
  • To discuss the ongoing challenges in personalizing immunosuppressive strategies.

Main Methods:

  • Review of historical and current literature on immunosuppression in transplantation.
  • Analysis of the immunobiology of organ rejection.
  • Examination of pharmacologic agents targeting T cells, B cells, and other immune components.

Main Results:

  • Early transplants in identical twins did not require immunosuppression.
  • Azathioprine and glucocorticosteroids enabled transplants between non-identical individuals.
  • Development of targeted immunosuppressants has improved transplant success rates.
  • Modern immunosuppression targets various immune cells and pathways, including T cells, B cells, plasma cells, costimulatory signals, complement products, and antidonor antibodies.

Conclusions:

  • Immunosuppressive therapy has been pivotal in making organ transplantation a clinical success.
  • Significant progress has been made in understanding and modulating the immune response to transplanted organs.
  • Personalizing immunosuppressive therapy remains a critical area for future research and clinical application.